Medically reviewed by Anand Thakkar, MD, MSCP. Last updated: September 29, 2026.
P Shot benefits get a lot of hype online. Some clinics make big promises. Others dismiss the treatment. The truth sits in between.
The P-Shot is a PRP penile injection, often called the P-Shot or Priapus Shot. It uses platelet rich plasma (PRP) made from your own blood. PRP is rich in growth factors. At Bliss MD, we give each PRP injection with ultrasound guidance as part of a wider sexual health plan. Learn about our P Shot Chicago care.
In This Article
How the P-Shot Is Thought to Work
Platelets release growth factors that help tissue repair. Placing them in penile tissue may support:
- Healthier blood vessels and better blood flow
- Nerve and tissue repair
- Firmer, more reliable erections over time
Early research supports this idea, but it is not settled science.
Potential P Shot Benefits Men Seek
Firmer, More Reliable Erections
This is the main reason men ask about a men’s P Shot. Many of our patients report firmer erections that last longer. Results vary, and not every man responds.
Less Reliance on Pills
Some men hope to need ED pills less often, or want an option when pills stop working well.
Peyronie's Disease
Small studies have looked at PRP for the curve caused by Peyronie’s disease. The data are limited, so we discuss it case by case.1
Confidence and Sexual Performance
When erections become more predictable, worry about sexual performance often eases. Be careful with ads about size or enhancing sexual stamina. PRP is not an evidence-based size treatment.
What the Research Says
- Guidelines. The American Urological Association (AUA) considers PRP for erectile dysfunction (ED) experimental.2 It is not FDA-approved for ED.
- A positive trial. In a 2021 trial of 60 men with mild to moderate ED, 69% on PRP reached a meaningful improvement at six months, compared with 27% on placebo.3
- A neutral trial. A 2023 trial of 61 men found no difference between PRP and placebo.4
- Reviews. A 2024 review of 17 studies found small-to-moderate benefits and mild, short-lived side effects.1
Bottom line: the evidence is still emerging, and results vary.
P Shot Benefits vs. Marketing Claims
Ads for the PRP penile injection, often called the P-Shot, can promise more than studies show. Here’s how common claims compare with the evidence.
| Claim you may see | What the evidence shows |
|---|---|
| “Firmer erections” | Possible for some men with mild to moderate ED. Trials are mixed. |
| “Bigger size” | Not supported. PRP is not an evidence-based size treatment. |
| “Pain-free” | We use numbing cream, but most men feel pressure and some soreness afterward. |
| “Results last for years” | Unknown. Studies follow men for months, not years. |
| “Fixes Peyronie’s curve” | Limited data. Small studies suggest it may help pain more than curve. |
| “FDA-approved” | No. PRP isn’t FDA-approved for ED or Peyronie’s disease, and the AUA calls it experimental for ED. |
Realistic P Shot benefits mean more reliable erections for some men. Not every man responds.
When You Might Notice P Shot Benefits
Everyone responds differently, and some men don’t notice a change. When changes happen, they usually follow this pattern:
- First 1–3 days: soreness, mild swelling or bruising. This isn’t a sign of results.
- Weeks 2–6: some men notice firmer morning erections.
- Months 3–6: when clinical trials checked results.
- Month 3 and later: we review your response and decide whether a second treatment makes sense. See P Shot cost for series pricing.
Why Bliss MD
- Board-certified internist since 2011, and A4M/ABAARM board certified in regenerative medicine
- Ultrasound-guided PRP injections
- Hormone, metabolic and heart health review before treatment
- Clinics in Lincoln Park and our Schaumburg-area clinic in Hanover Park
What to Expect: Before, During and After
Before
We start with a medical visit and labs. Tell us about blood thinners and supplements.
During
We draw a small amount of blood and concentrate the platelets. After numbing cream, Dr. Thakkar injects the PRP under ultrasound. The visit takes about an hour.
After
Most men return to normal activities the same day. You may need a short break from sex. Some clinicians also suggest a vacuum erection device (VED). Changes, if they happen, build over weeks to months.
Curious whether you’re a good candidate?
P-Shot Side Effects and Risks
Common side effects are usually short-lived:
- Soreness or tenderness
- Bruising or swelling
- Minor bleeding at the injection site
Less common risks include infection and temporary changes in sensation. PRP comes from your own blood, so allergic reactions are unlikely.
Who May Be a Good Candidate?
The P-Shot is often discussed for men with mild to moderate ED, or men whose pills work less well. If you’re searching for a P Shot for men near me, choose a clinic that checks the causes first. Men with severe vascular disease may need other treatments.
P-Shot in Lincoln Park and Hanover Park
Our Lincoln Park clinic is at 2707 N Halsted, just south of Diversey. Men in the northwest suburbs can visit our Schaumburg-area clinic in Hanover Park. At both clinics, Dr. Thakkar reviews your hormones, heart health and medications before any injection, so you get an honest view of likely P Shot benefits. Dr. Thakkar is board certified in Internal Medicine (ABIM), with additional certification from A4M/ABAARM.
Getting More From Your Treatment
- Hormones. Read about low testosterone and ED, low testosterone symptoms, hormone replacement therapy in Chicago and testosterone pellets.
- Regenerative add-ons. See our guide to exosomes, stem cells and venous leak.
- Shockwave or medications. Learn about shockwave therapy, compare P-Shot vs shockwave vs ED medication, or read about PT-141 and compounded ED medications.
- Weight and exercise. In one trial, obese men who lost weight and exercised more saw erectile function improve.5
Frequently Asked Questions About P Shot Benefits
Does the P-Shot work?
For some men, yes. Studies are mixed, and results vary.
How long do results last?
No one knows for sure. Studies have short follow-up. Some men repeat treatment over time.
What is the P Shot cost near me?
At Bliss MD, the P Shot cost is typically $1,000 to $2,500 per treatment at either clinic. See P Shot cost in Chicago.
How do I choose a P Shot near me?
Whether you search “P Shot near me” or “Priapus Shot near me,” look for a physician who checks your health first and uses imaging. Men choosing a Priapus Shot Chicago clinic can visit us in Lincoln Park or our Schaumburg-area clinic in Hanover Park.
Does the P-Shot increase size?
There’s no good evidence that it does. We don’t offer PRP as a size treatment.
Who shouldn't get the P-Shot?
Men with an active infection, a bleeding disorder, certain blood cancers or low platelets usually aren’t candidates. Men with severe vascular disease may do better with other options. We review your health first.
Is the P-Shot painful?
We apply numbing cream first. Most men feel pressure during the injection and mild soreness for a day or two.
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References
- Systematic review of PRP for ED and Peyronie’s disease. World J Urol. 2024. https://link.springer.com/article/10.1007/s00345-024-05065-3
- American Urological Association. Erectile Dysfunction Guideline. https://www.auanet.org/guidelines-and-quality/guidelines/erectile-dysfunction-(ed)-guideline
- Poulios E, et al. J Sex Med. 2021. https://pubmed.ncbi.nlm.nih.gov/33906807/
- Masterson TA, et al. J Urol. 2023. https://pubmed.ncbi.nlm.nih.gov/37120727/
- Esposito K, et al. JAMA. 2004. https://pubmed.ncbi.nlm.nih.gov/15213209/
For educational purposes only. PRP is not FDA-approved for erectile dysfunction, and results vary. Please consult a licensed physician before starting treatment.
